A series of fluorinated analogs of malachite green (MG) have been synthesizedand their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell lineexamined. The toxicity profiles were found to be different for these two species. Twoanalogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem tobe the most promising analogs because they showed the lowest toxicity to the human cells.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
George A. Kraus, Insik Jeon, Marit Nilsen-Hamilton, Ahmed M. Awad, et al.. "Fluorinated Analogs of Malachite Green: Synthesis and Toxicity" Molecules
Vol. 13 Iss. 4 (2008) p. 986 - 994
Available at: http://works.bepress.com/marit-nilsen-hamilton/18/