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Unpublished Paper
Secreted proteins, intercellular communication, and the mitogenic response
Cell Biology International Reports (1982)
  • Marit Nilsen-Hamilton, Salk Institute
  • Richard T. Hamilton, Salk Institute
Living organisms, from the simplest prokaryote,
have developed the means of modifying their environment
to suit their needs. Cells accomplish this by synthesizing
and secreting environmental modifiers that are
often proteins with a catalytic activity - e.g., enzymes
that degrade extracellular macromolecules to provide a
source of nutrients. They also secrete toxins that
diminish competition from other species. In multicellular
organisms, other environmental problems have had to
be solved - e.g., the creation of the tissue matrix to
hold the cells together. Thus, eukaryotic cells secrete
glycoproteins, glycosaminoglycans and other components
of extracellular matrices and basal laminae.
Publication Date
This is an article from Cell Biology International Reports 6 (1982): 815, doi:10.1016/0309-1651(82)90142-4. Posted with permission.
Citation Information
Marit Nilsen-Hamilton and Richard T. Hamilton. "Secreted proteins, intercellular communication, and the mitogenic response" Cell Biology International Reports (1982)
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Creative Commons License
Creative Commons License
This work is licensed under a Creative Commons CC_BY-NC International License.