ObjectivesFew studies have explored mindfulness and nonattachment in Arab populations. This study extends our understanding of mindfulness and nonattachment to Arab students in the United Arab Emirates (UAE) based on the 20-item Five Facet Mindfulness Questionnaire (FFMQ) and the 7-item Nonattachment Scale (NAS-7). This study investigated the model fit of each measure, in conjunction with examining the measurement invariance of both measures across Emirati and Australian samples. Next, this study investigated the mediating role of nonattachment.MethodsUniversity students from the UAE (N = 452) and Australia (N = 731) completed self-report measures of mindfulness, nonattachment, positive and negative affect, and depression, stress, and anxiety.ResultsFor the FFMQ, a four-factor model—excluding the facet Observe but with the addition of covariance between two items from the facet Describe—provided adequate fit in both samples. The NAS-7 provided adequate fit in the Australian sample but not the UAE. While the FFMQ model was invariant across samples, the NAS-7 was non-invariant, thus preventing sample comparison. Overall, nonattachment partially mediated the relationship between mindfulness and well-being with differences across samples.ConclusionsFindings support the use of a four-factor model of the FFMQ in Emirati samples and attest to its robustness and suitability as a measure for cross-cultural comparisons. Findings also support a partial mediating role for nonattachment and attest to the intricacies of the Emirati culture.