18 healthy adult cows were used to determine whether epidural administration of detomidine hydrochloride to cattle induced analgesia of the perineum and to compare analgesic and systemic effects of epidural versus i.m. administration of detomidine at a dose of 40 g/kg. 6 cows were given detomidine by epidural administration, 6 were given detomidine i.m. and 6 (control group) were not given detomidine. Analgesia was assessed by determining responses to needle pin-pricks in the perineum and flank and by applying electrical stimuli to the perineum and flank and determining the voltage that induced an avoidance response. Degree of sedation and ataxia were scored, and mean arterial pressure, heart rate, respiratory rate and frequency of ruminal contractions were measured. Epidural and i.m. administration of detomidine induced comparable degrees of analgesia of the perineum and flank, accompanied by moderate sedation and ataxia, hypertension, cardiorespiratory depression and rumen hypomotility. It is concluded that epidural and i.m. administration of detomidine at a dose of 40 g/kg induced similar analgesic and systemic effects in cattle.
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