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Article
Comparison of the Separation Behavior of Benzodiazepines in Packed Capillary Electrochromatography and Open-Tubular Electrochromatography
Journal of Chromatography A (2000)
  • K. Jinno, Toyohashi University of Technology
  • H. Sawada, Toyohashi University of Technology
  • A. P. Catabay, Toyohashi University of Technology
  • H. Watanabe, Toyohashi University of Technology
  • N. B.H. Sabli, Toyohashi University of Technology
  • J. J. Pesek, San Jose State University
  • Maria T. Matyska-Pesek, San Jose State University
Abstract

Packed column capillary electrochromatography (CEC), open-tubular CEC and microcolumn liquid chromatography (LC) using a cholesteryl silica bonded phase have been studied to compare the retention behavior for benzodiazepines. It has been found that packed column CEC gives better resolution, faster analysis time than microcolumn LC for benzodiazepines maintaining similar selectivity except for some solutes which are charged species under the separation conditions. However, open-tubular CEC gave different selectivities to a larger extent for charged benzodiazepines from that which should be produced by the chromatographic properties of the cholesteryl silica phase. Charged species migration times are mainly influenced by electrophoretic mobility rather than the chromatographic interactions.

Disciplines
Publication Date
2000
Publisher Statement
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Citation Information
K. Jinno, H. Sawada, A. P. Catabay, H. Watanabe, et al.. "Comparison of the Separation Behavior of Benzodiazepines in Packed Capillary Electrochromatography and Open-Tubular Electrochromatography" Journal of Chromatography A Vol. 887 Iss. 1-2 (2000)
Available at: http://works.bepress.com/maria_matyska-pesek/77/