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Article
Evaluation of the Silanization/Hydrosilation Process for the synthesis od Chiral Stationary Phases
Chromatographia (2001)
  • J. J. Pesek, San Jose State University
  • Maria T. Matyska-Pesek, San Jose State University
  • Pik Fong Fu, San Jose State University
Abstract

The silanization/hydrosilation bonding method is used to attach four different chiral olefins to a silica hydride surface. Three of these olefins ((R)-(+)-limonene, (R)-(+)-acroyloxy-β,β-dimethyl-λ-butyrolactone and 2-hydroxy-3-methacryloyloxypropyl-β-cyclodextrin) are successfully bonded to the hydride intermediate as confirmed by DRIFT and solid state NMR spectroscopy. Chromatographic evaluation of these three chiral stationary phases using a number of test solutes resulted in no separations of enantiomers for the limonene phase, two marginal resolutions for the lactone phase and six successful separations for the β-cyclodextrin material. Among the types of compounds that were resolved on the β-cyclodextrin column were benzodiazepines, danysl amino acids and a novel selenium compound.

Disciplines
Publication Date
2001
Publisher Statement
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Citation Information
J. J. Pesek, Maria T. Matyska-Pesek and Pik Fong Fu. "Evaluation of the Silanization/Hydrosilation Process for the synthesis od Chiral Stationary Phases" Chromatographia Vol. 53 Iss. 11-12 (2001)
Available at: http://works.bepress.com/maria_matyska-pesek/72/