Skip to main content
Article
Synthesis and Chromatographic Evaluation of Carboxylic Acid Phases on a Hydride Surface
Journal of Separation Science (2006)
  • J. J. Pesek, San Jose State University
  • Maria T. Matyska-Pesek, San Jose State University
  • S. Gangakhedkar
  • R. Siddiq
Abstract

Three organic moieties containing carboxylic acid functional groups are attached to a particulate silica surface through silanization/hydrosilation. Two compounds (undecylenic acid and 10-undecynoic acid) have 11 carbon chains and the other is a five-carbon acid (pentenoic acid). Bonding is confirmed through carbon elemental analysis, diffuse reflectance infrared fourier transform spectroscopy, and carbon-13 and silicon-29 CP-MAS NMR spectroscopy. The bonded phases are tested by HPLC using PTH amino acids, nucleic acids, theophylline-related compounds, anilines, benzoic acid compounds, choline, and tobramycin. The latter two compounds are used to investigate the aqueous normal phase properties of the three bonded materials.

Disciplines
Publication Date
2006
Publisher Statement
SJSU users: use the following link to login and access the article via SJSU databases
Citation Information
J. J. Pesek, Maria T. Matyska-Pesek, S. Gangakhedkar and R. Siddiq. "Synthesis and Chromatographic Evaluation of Carboxylic Acid Phases on a Hydride Surface" Journal of Separation Science Vol. 29 Iss. 6 (2006)
Available at: http://works.bepress.com/maria_matyska-pesek/39/