This article examines the evolution of Portland, Oregon, as one of 33 “first-generation” cities that participated in the World Health Organization’s (WHO) Global Age-Friendly Cities (AFC) project in 2006–2007. The Age-Friendly Portland initiative is a university-city-community collaborative that is working to establish age-friendly planning goals defined in the City of Portland’s public planning documents. These planning documents represent the City’s public policies for land use, transportation, housing, and economic development, and other areas. However, policies lack meaning unless they are implemented (Mazmanian & Sabatier, 1989). In the following sections we briefly describe Portland’s initial history with the AFC project, explain how age-friendly ideas were included on the City’s planning agenda, and then describe current implementation strategies, activities, and plans. We also discuss the translational research process and how we have begun evaluating the work.