Several different arterial puncture closure devices are available for use after cardiovascular procedures. The main advantages include decrease need of manual compression, reduce patient discomfort, and the time to ambulation. Access site complications are not rare after vascular closure device use. We report a case of popliteal artery embolization after using an extravascular water soluble plug-mediated vascular puncture closure device. Copyright 2009 Wiley-Liss, Inc.