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Results of Lung Cancer Screening in the Community.
Annals of family medicine
  • John R Handy, Providence Cancer Center, Portland, OR
  • Michael Skokan
  • Erika Rauch, Providence Cancer Center, Portland, OR
  • Steven Zinck
  • Rachel E Sanborn, Earle A. Chiles Research Institute, Providence Cancer Center, Portland, OR
  • Svetlana Kotova, Department of Thoracic Surgery, Providence Cancer Institute, Portland, Oregon.
  • Mansen Wang, Medical Data Research Center, Providence Health and Services, Portland, OR, USA
Document Type
Publication Date
  • oregon,
  • portland,
  • Aged,
  • Aged, 80 and over,
  • Community Health Services,
  • Early Detection of Cancer,
  • Female,
  • Humans,
  • Lung Neoplasms,
  • Male,
  • Mass Screening,
  • Middle Aged,
  • Prospective Studies,
  • Radiology,
  • Referral and Consultation,
  • Retrospective Studies

PURPOSE: To address doubts regarding National Lung Screening Trial (NLST) generalizability, we analyzed over 6,000 lung cancer screenings (LCSs) within a community health system.

METHODS: Our LCS program included 10 sites, 7 hospitals (2 non-university tertiary care, 5 community) and 3 free-standing imaging centers. Primary care clinicians referred patients. Standard criteria determined eligibility. Dedicated radiologists interpreted all LCSs, assigning Lung Imaging Reporting and Data System (Lung-RADS) categories. All category 4 Lung-RADS scans underwent multidisciplinary review and management recommendations. Data was prospectively collected from November 2013 through December 2018 and retrospectively analyzed.

RESULTS: Of 4,666 referrals, 1,264 individuals were excluded or declined, and 3,402 individuals underwent initial LCS. Second through eighth LCSs were performed on 2,758 patients, for a total of 6,161 LCSs. Intervention rate after LCS was 14.6% (500 individuals) and was most often additional imaging. Invasive interventions (n = 226) were performed, including 141 diagnostic procedures and 85 surgeries in 176 individuals (procedure rate 6.6%). Ninety-five lung cancers were diagnosed: 84 non-small cell (stage 1: 60; stage 2: 7; stage 3: 9; stage 4: 8), and 11 small cell lung cancers. The procedural adverse event rate was 23/226 (10.1%) in 21 patients (0.6% of all screened individuals). Pneumothorax (n = 10) was the most frequent, 6 requiring pleural drainage. There were 2 deaths among 85 surgeries or 2.3% surgical mortality.

CONCLUSIONS: Our LCS experience in a community setting demonstrated lung cancer diagnosis, stage shift, intervention frequency, and adverse event rate similar to the NLST. This study confirms that LCS can be performed successfully, safely, and with equivalence to the NLST in a community health care setting.

Clinical Institute
Earle A. Chiles Research Institute
Pulmonary Medicine
Citation Information
John R Handy, Michael Skokan, Erika Rauch, Steven Zinck, et al.. "Results of Lung Cancer Screening in the Community." Annals of family medicine (2020)
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