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Matevosyan NR. Periodontal disease and perinatal outcomes.
Archives of Gynecology and Obstetrics (Springer-Verlag) (2011)

Purpose To elucidate plausible associations between periodontal disease (PD) and pregnancy events through meta-analysis of original research published between 1998 and 2010.

Methods One hundred and twenty-five randomized, case–control, matched-cohort studies on pregnancy and postpartum specifics in women with PD are identified through PubMed, LILACS, and Cochrane Register. Meta-study is performed on a sample of 992 births allocated from studies of level I-II-1 evidence. An oral inflammation score (OIS) is composed from parameteric and observational components of maternal PD. Pearson arrival process is modeled for exchangeable correlations.

Results Women with preeclampsia and preterm birth have poor periodontal parameters in both, treatment and placebo groups (OR 1.94–2.9). In puerperae with severe periodontitis birth weight is negatively correlated with maternal probing depth (r = −0.368), and C-reactive protein (r = −0.416). Higher rates of tobacco use (RR 3.02), bacterial vaginosis (RR 2.7), clinical attachment level (OR 2.76), and fetal tyrosine kinase (OR 1.6) contribute in increased rates of preeclamsia (RR 1.68), and prematurity (RR 2.75). After adding confounders into the model OIS remains significantly associated with preterm birth (OR 2.3).

Conclusions Maternal PD has strong associations with preeclampsia and prematurity.

  • Periodontal disease – Oral pathogens – Preeclampsia – Preterm birth – Bacterial vaginosis
Publication Date
Winter December 1, 2011
Citation Information
"Matevosyan NR. Periodontal disease and perinatal outcomes." Archives of Gynecology and Obstetrics (Springer-Verlag) Vol. 283 Iss. 4 (2011)
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