Skip to main content
Thermoresponsive reversible behavior of multistimuli pluronic-based pentablock copolymer at the air-water interface
  • Sergiy Peleshanko, Iowa State University
  • Kyle D. Anderson, Iowa State University
  • Matthew Dave Goodman, Iowa State University
  • Michael Duane Determan, Iowa State University
  • Surya K. Mallapragada, Iowa State University
  • Vladimir V. Tsukruk, Georgia Institute of Technology - Main Campus
Document Type
Publication Date
Surface behavior of the pH- and thermoresponsive amphiphilic ABCBA pentablock copolymer has been studied with respect to the environmental conditions. We demonstrate that the pentablock copolymer poly((diethylaminoethyl methacrylate)-b-(ethylene oxide)-b-(propylene oxide)-b-(ethylene oxide)-b-(diethylaminoethyl methacrylate)) possesses reversible temperature changes at the air-water interface in a narrow pH range of the water subphase. Significant diversity in the surface morphology of pentablock copolymer monolayers at different pH and temperatures observed were related to the corresponding reorganization of central and terminal blocks. Remarkable reversible variations of the surface pressure observed for the Langmuir monolayers at pH 7.4 in the course of heating and cooling between 27 and 50°C is associated with conformational transformations of terminal blocks crossing the phase line in the vicinity of the lower critical solution temperature point. The observed thermoresponsive surface behavior can be exploited for modeling of the corresponding behavior of pentablock copolymers adsorbed onto various biointerfaces for intracellular delivery for deeper understanding of stimuli-responsive transformations relevant to controlled drug and biomolecules release and retention.

Reprinted with permission from Langmuir 23 (2007), pp.25-30, doi: 10.1021/la061547f. Copyright 2007 American Chemical Society.

Copyright Owner
American Chemical Society
File Format
Citation Information
Sergiy Peleshanko, Kyle D. Anderson, Matthew Dave Goodman, Michael Duane Determan, et al.. "Thermoresponsive reversible behavior of multistimuli pluronic-based pentablock copolymer at the air-water interface" Langmuir Vol. 23 Iss. 1 (2007) p. 25 - 30
Available at: