Synthesis and evaluation of the diarylthiourea analogs as novel anti-cancer agentsBioorganic & Medicinal Chemistry Letters (2015)
en p-nitrodiarylthiourea analogs were designed, synthesized and evaluated in breast (MCF-7, T-47D, MDA-MB-453) and prostate (DU-145, PC-3, LNCaP) cancer cell lines for their anticancer activities. The majority of the compounds were able to inhibit the growth of these six cancer cell lines at low micromolar concentrations. Compound 7 was found to be the most potent anticancer agent in this series with GI50 values of 3.16 μM for MCF-7, 2.53 μM for T-47D, 4.77 μM for MDA-MB-453 breast cancer lines and 3.54 μM for LNCaP prostate cancer cell line. These GI50 values were comparable to the parent compound, SHetA2.
Publication DateMarch 15, 2015
Citation InformationShengquan Liu, Maggie C. Louie, Vanishree Rajagopalan, Guangyan Zhou, et al.. "Synthesis and evaluation of the diarylthiourea analogs as novel anti-cancer agents" Bioorganic & Medicinal Chemistry Letters Vol. 25 Iss. 6 (2015) p. 1301 - 1305 ISSN: 0960-894X
Available at: http://works.bepress.com/maggie_louie/15/