Skip to main content
Article
Synthesis and evaluation of the diarylthiourea analogs as novel anti-cancer agents
Bioorganic & Medicinal Chemistry Letters (2015)
  • Shengquan Liu, College of Pharmacy, Touro University-California
  • Maggie C. Louie, Dominican University of California
  • Vanishree Rajagopalan, College of Pharmacy, Touro University-California
  • Guangyan Zhou, Department of Basic Science, Touro University-California
  • Esmeralda Ponce, Department of Natural Science and Mathematics, Dominican University of California
  • Tran Nguyen, College of Pharmacy, Touro University-California
  • Linda Green, Department of Natural Science and Mathematics, Dominican University of California
Abstract
en p-nitrodiarylthiourea analogs were designed, synthesized and evaluated in breast (MCF-7, T-47D, MDA-MB-453) and prostate (DU-145, PC-3, LNCaP) cancer cell lines for their anticancer activities. The majority of the compounds were able to inhibit the growth of these six cancer cell lines at low micromolar concentrations. Compound 7 was found to be the most potent anticancer agent in this series with GI50 values of 3.16 μM for MCF-7, 2.53 μM for T-47D, 4.77 μM for MDA-MB-453 breast cancer lines and 3.54 μM for LNCaP prostate cancer cell line. These GI50 values were comparable to the parent compound, SHetA2.
Disciplines
Publication Date
March 15, 2015
DOI
Citation Information
Shengquan Liu, Maggie C. Louie, Vanishree Rajagopalan, Guangyan Zhou, et al.. "Synthesis and evaluation of the diarylthiourea analogs as novel anti-cancer agents" Bioorganic & Medicinal Chemistry Letters Vol. 25 Iss. 6 (2015) p. 1301 - 1305 ISSN: 0960-894X
Available at: http://works.bepress.com/maggie_louie/15/