Asphalt binder requires more investigation to be accurately and precisely extracted since it is an effective procedure for quality assurance quality control (QA/QC) and subsequent binder characterization. In this research, the authors presented a hands-on experience with binder extraction to deliver recommendations concerning the sensitive steps that may affect the outcomes (extracted binder content, Pbe%). Two mineral matter determination methods (ashing and centrifuge) were addressed based on the centrifuge extraction method. Field cores were investigated by comparing the Pbe% to the actual binder content, Pba%. Analysis of variance (ANOVA) and Tukey Post-Hoc statistical analyses, in addition to linear least square regression analysis, were used to show the significance of difference according to 38 variant cores randomly obtained from the field segments (in-service roads) via the first two weeks from their construction dates. Such cores involved reclaimed asphalt pavement (RAP), reclaimed asphalt shingles (RAS), and a wide range of additives. The two extraction methods were compared, concluding that the centrifuge method was highly recommended based on a quantitative evaluation, which delivered the same average Pba% based on the 38 cores. Furthermore, the centrifuge method provided much saving in the experimental time (almost half the time required for the ashing method). It was found that the ashing outcomes were equal to the centrifuge outcomes when disregarding the ammonium carbonate addition. Thus, it could be recommended to reassess the ammonium carbonate addition as it might excessively compensate for minerals that have not been lost by the ignition oven.