The use of recycled materials in asphalt applications is growing rapidly. Adding crumb rubber (CRM) improves the performance of different asphalt applications. Modifications to asphalt properties using CRM are slightly different as compared to those of virgin polymers. Certain asphalt properties are modified more effectively using virgin polymers. Enhancing the performance of asphalt-rubber (CRM) applications through the addition of polymer modifiers has been successful. Modifiers can also improve the handling and workability of CRM binders and mixes. This paper documents some of the key efforts using CRM modification with enhanced performance through the addition of polymer modifiers. The paper provides some clear insights into the mechanisms by which the interaction, with and without the existence of polymer modifiers, takes place. The effects of the interaction process variables, time and temperature and preprocessing, are explained. The results of this research are based on monitoring the changes in the rheological parameters of the developed binder. The extent of using virgin polymers, in addition to CRM, to achieve specific asphalt modification is discussed.