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Membrane cytoskeleton: PIP(2) pulls the strings
Women’s Health Research Faculty Publications
  • Thomas Nebl, University of Massachusetts Medical School
  • Sang W. Oh, University of Massachusetts Medical School
  • Elizabeth J. Luna, University of Massachusetts Medical School
UMMS Affiliation
Department of Cell Biology
Publication Date
Document Type
Animals; Calcium; Cell Membrane; Cytoskeleton; Humans; Isoenzymes; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C; Phospholipase C gamma; Phosphoric Monoester Hydrolases
A recent application of optical tweezers has shown that plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)) levels control adhesion of the membrane bilayer to the underlying cytoskeleton, by regulated direct binding of PIP(2) to cytoskeletal proteins and/or indirect effects on cytoskeleton structure.
Curr Biol. 2000 May 4;10(9):R351-4.
Related Resources
Link to article in PubMed
PubMed ID
Citation Information
Thomas Nebl, Sang W. Oh and Elizabeth J. Luna. "Membrane cytoskeleton: PIP(2) pulls the strings" Vol. 10 Iss. 9 (2000) ISSN: 0960-9822 (Print)
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