Influence of Interleukin-2 Deficiency on the Generation of Autoimmune B CellsJournal of Autoimmunity
AbstractThe production of auto-antibodies is one of the predominant characteristics of autoimmune disorders. Because IL-2 deficient mice develop autoimmunity, we asked how IL-2 deficiency might impair endogenous mechanisms of B cell tolerance. To this end, we mated BALB/c anti-dsDNA H chain knock-in mice, in which B cells producing anti-dsDNA antibodies are properly regulated, with IL-2 deficient mice and assessed the phenotype of their offspring. IL-2 deficient mice expressing the anti-dsDNA H chain knock-in allele developed anti-dsDNA antibodies of both IgM and IgG isotypes. Production of these antibodies occurred through the disruption of several mechanisms of endogenous tolerance, including deletion, maturational arrest, and follicular exclusion. In summary, our results suggest that IL-2 plays an important role in regulating B cell tolerance.
Citation InformationLucile E. Wrenshall, Deandra R. Smith, Elliot T. Stevens and John D. Miller. "Influence of Interleukin-2 Deficiency on the Generation of Autoimmune B Cells" Journal of Autoimmunity Vol. 29 Iss. 2-3 (2007) p. 125 - 133 ISSN: 08968411
Available at: http://works.bepress.com/lucile_wrenshall/65/