Skip to main content
Article
Increased Pancreatitis in Allografts Flushed with Histidine-Tryptophan-Ketoglutarate Solution: a Cautionary Tale
American Journal of Transplantation
  • D. Alonso
  • T. B. Dunn
  • Theodore H. Rigley
  • Jill Y. Skorupa
  • M. E. Schriner
  • Lucile E. Wrenshall, Wright State University - Main Campus
  • R. Brian Stevens, Wright State University
Document Type
Article
Publication Date
8-12-2008
Abstract
We reviewed pancreas transplantation outcomes after Histidine-Tryptophan-Ketoglutarate (HTK) and University of Wisconsin (UW) preservation solution use between 2001 and 2007 at two transplant centers. While equivalence has been claimed for kidney and liver transplant outcomes after the use of HTK or UW preservation solution, consensus has not been reached on equivalence when flushing pancreata. Others have reported comparable patient and graft survival rates, but found an association between the use of HTK and an increase in the incidence of acute rejection and pancreatitis. In reviewing our experiences, we found in pancreata flushed with HTK a higher incidence of postoperative complications including graft pancreatitis, use of octreotide and a decreased rate of insulin-independence at hospital discharge. These findings prompted us to critically review our centers' experience to determine if there is a basis for suspecting a causal relationship.
Comments

Spanish version available here.

DOI
10.1111/j.1600-6143.2008.02312.x
Citation Information
D. Alonso, T. B. Dunn, Theodore H. Rigley, Jill Y. Skorupa, et al.. "Increased Pancreatitis in Allografts Flushed with Histidine-Tryptophan-Ketoglutarate Solution: a Cautionary Tale" American Journal of Transplantation Vol. 8 Iss. 9 (2008) p. 1942 - 1945 ISSN: 16006135
Available at: http://works.bepress.com/lucile_wrenshall/58/