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Propagation and Control of T Cell Responses by Heparan Sulfate-Bound IL-2
The Journal of Immunology
  • Lucile E. Wrenshall, Wright State University - Main Campus
  • Jeffrey L. Platt
  • Elliot T. Stevens
  • Thomas N. Wight
  • John D. Miller
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IL-2, a cytokine produced by T cells, is a key regulator of immune responses and T cell homeostasis. Controlling the availability of IL-2 is consequently of significant import to the immune system. Like other cytokines, IL-2 is thought to function as a soluble agonist, transiently present when secreted in response to appropriate stimuli. In this study, we show that the most salient properties of IL-2, propagation and control of T cell responses, are mediated in vivo by bound and not free cytokine and specifically by heparan sulfate-bound IL-2. These findings necessitate a new look at how IL-2 regulates immune responses and support the notion that the microenvironment plays a determining role in modulating the character of immune responses.
Citation Information
Lucile E. Wrenshall, Jeffrey L. Platt, Elliot T. Stevens, Thomas N. Wight, et al.. "Propagation and Control of T Cell Responses by Heparan Sulfate-Bound IL-2" The Journal of Immunology Vol. 170 Iss. 11 (2003) p. 5470 - 5474 ISSN: 00221767
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