Regulation of T Cell Homeostasis by Heparan Sulfate-Bound IL-2The Journal of Immunology
AbstractAlthough IL-2 is commonly thought to promote proliferation of T lymphocytes, mice deficient in IL-2 exhibit splenomegaly, lymphocytosis, and autoimmunity, suggesting this cytokine may have a prominent role in T cell homeostasis. Since the number of T cells in the bloodstream and lymphoid organs is tightly controlled, it is likely that the availability of IL-2 must also be closely regulated. One mechanism altering the local availability of cytokines is association with heparan sulfate, a glycosaminoglycan found on cell surfaces and within extracellular matrices. Here we show that an association between IL-2 and heparan sulfate localizes IL-2 to lymphoid organs such as the spleen. We also show that IL-2, sequestered in this way, contributes to the activation of T lymphocytes and primes T lymphocytes for activation-induced cell death.
Citation InformationLucile E. Wrenshall and Jeffrey L. Platt. "Regulation of T Cell Homeostasis by Heparan Sulfate-Bound IL-2" The Journal of Immunology Vol. 163 Iss. 7 (1999) p. 3793 - 3800 ISSN: 00221767
Available at: http://works.bepress.com/lucile_wrenshall/28/