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Article
Improving Detection of Clinically Significant Prostate Cancer: MRI/TRUS Fusion-Guided Prostate Biopsy
J Urol
  • A. R. Rastinehad
  • B. Turkbey
  • S. S. Salami
  • O. Yaskiv, Hofstra Northwell School of Medicine
  • A. K. George, Northwell Health
  • M. Fakhoury
  • K. Beecher
  • M. A. Vira, Hofstra Northwell School of Medicine
  • L. R. Kavoussi, Hofstra Northwell School of Medicine
  • D. N. Siegel, Hofstra Northwell School of Medicine
  • R. Villani, Hofstra Northwell School of Medicine
  • E. Ben-Levi, Hofstra Northwell School of Medicine
Publication Date
2013
Abstract
PURPOSE:: Given the limitations of prostate specific antigen and standard biopsies in detecting prostate cancer (CaP), we evaluate the Cancer Detection Rate (CDR) and external validity of Magnetic Resonance Imaging/Transrectal Ultrasound (MR/TRUS) fusion-guided prostate biopsy system being utilized at NIH. MATERIALS AND METHODS:: Phase-III Trial of MR/TRUS fusion-guided prostate biopsy system with participants enrolled between 2012 and 2013. 153 men consented to the study who underwent a 3T multi-parametric MRI with an endorectal coil for a clinical suspicion for CaP and had lesions classified into low or moderate/high risk for CaP. MR/TRUS fusion-guided biopsies and standard 12-core prostate biopsies were performed, and 105 men were eligible for analysis. RESULTS:: The mean age and PSA were 65.8 years and 9.5ng/mL respectively. The overall CDR was 62.9 % (66/105). The CDR in those with moderate/high risk on MP-MRI was 72.3% (47/65) versus 47.5% (19/40) in those classified as low risk for CaP (p
Pages
1749-54
Document Type
Article
EPub Date
2013/12/18
Status
Faculty; Northwell Researcher
Facility
School of Medicine; Northwell Health
Primary Department
Urology
Additional Departments
Radiology
PMID

24333515

DOI
10.1016/j.juro.2013.12.007
Disciplines
Citation Information
A. R. Rastinehad, B. Turkbey, S. S. Salami, O. Yaskiv, et al.. "Improving Detection of Clinically Significant Prostate Cancer: MRI/TRUS Fusion-Guided Prostate Biopsy" J Urol Vol. 191 Iss. 6 (2013)
Available at: http://works.bepress.com/louis-kavoussi/21/