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Investigation of an inducible nitric oxide synthase gene (NOS2A) polymorphism in a multiple sclerosis population
Brain research bulletin (2004)
  • Lotti Tajouri, Griffith University
  • Virginie Martin, Griffith University
  • Micky Ovcaric, Griffith University
  • Rob P. Curtain, Griffith University
  • Rod A. Lea
  • Peter Csurhes, University of Queensland
  • Michael P. Pender, University of Queensland
  • Lyn R. Griffiths, Griffith University
Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) affecting most commonly the Caucasian population. Nitric oxide (NO) is a biological signaling and effector molecule and is especially important during inflammation. Inducible nitric oxide synthase (iNOS) is one of the three enzymes responsible for generating NO. It has been reported that there is an excessive production of NO in MS concordant with an increased expression of iNOS in MS lesions. This study investigated the role of a bi-allelic tetranucleotide polymorphism located in the promoter region of the human iNOS (NOS2A) gene in MS susceptibility. A group of MS patients (n = 101) were genotyped and compared to an age- and sex-matched group of healthy controls (n = 101). The MS group was subdivided into three subtypes, namely relapsing-remitting MS (RR-MS), secondary-progressive MS (SP-MS) and primary-progressive MS (PP-MS). Results of a chi-squared analysis and a Fisher’s exact test revealed that allele and genotype distributions between cases and controls were not significantly different for the total population (χ2 = 3.4, P genotype = 0.15; χ2 = 3.4, P allele = 0.082) and for each subtype of MS (P > 0.05). This suggests that there is no direct association of this iNOS gene variant with MS susceptibility.

Keywords
  • multiple sclerosis,
  • gene association,
  • iNOS,
  • polymorphism
Publication Date
July 30, 2004
Publisher Statement
Interim status: Citation only.

Tajouri, L., Martin, V., Ovcaric, M., Curtain, R. P., Lea, R. A., Csurhes, P., Pender, M. P., & Griffiths, L. R. (2004). Investigation of an inducible nitric oxide synthase gene (NOS2A) polymorphism in a multiple sclerosis population. Brain research bulletin, 64(1), 9-13.

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© Copyright 2004 Elsevier Inc. All rights reserved.
Citation Information
Lotti Tajouri, Virginie Martin, Micky Ovcaric, Rob P. Curtain, et al.. "Investigation of an inducible nitric oxide synthase gene (NOS2A) polymorphism in a multiple sclerosis population" Brain research bulletin Vol. 64 Iss. 1 (2004)
Available at: http://works.bepress.com/lotti_tajouri/15/