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United States Acculturation and Cancer Patients’ End-of-Life Care
Women’s and Gender Studies Faculty Publication Series
  • Alexi A. Wright, Dana-Farber Cancer Institute
  • Heather Stieglitz, Parkland Center for Clinical Innovation
  • Yankel M. Kupersztoch, University of Texas Southwestern Medical Center
  • M. Elizabeth Paulk, University of Texas Southwestern Medical Center
  • Yookyung Kim, University of Pittsburgh School of Medicine
  • Ingrid T. Katz, Harvard Medical School
  • Francisco Munoz, Pomona Valley Hospital Medical Center
  • Rachel B. Jimenez, Dana-Farber Cancer Institute
  • Jan Mutchler, University of Massachusetts Boston
  • Lorna Rivera, University of Massachusetts Boston
  • Anthony L. Back, Fred Hutchinson Cancer Research Center & University of Washington
  • Holly G. Prigerson, Dana-Farber Cancer Institute
Document Type
Article
Publication Date
3-11-2013
Abstract
Background: Culture shapes how people understand illness and death, but few studies examine whether acculturation influences patients’ end-of-life treatment preferences and medical care. Methods and Findings: In this multi-site, prospective, longitudinal cohort study of terminally-ill cancer patients and their caregivers (n = 171 dyads), trained interviewers administered the United States Acculturation Scale (USAS). The USAS is a 19- item scale developed to assess the degree of ‘‘Americanization’’ in first generation or non-US born caregivers of terminally-ill cancer patients. We evaluated the internal consistency, concurrent, criterion, and content validity of the USAS. We also examined whether caregivers’ USAS scores predicted patients’ communication, treatment preferences, and end-of-life medical care in multivariable models that corrected for significant confounding influences (e.g. education, country of origin, English proficiency). The USAS measure was internally consistent (Cronbach a = 0.98); and significantly associated with US birthplace (r = 0.66, P,0.0001). USAS scores were predictive of patients’ preferences for prognostic information (AOR = 1.31, 95% CI:1.00–1.72), but not comfort asking physicians’ questions about care (AOR 1.23, 95% CI:0.87–1.73). They predicted patients’ preferences for feeding tubes (AOR = 0.68, 95% CI:0.49–0.99) and wish to avoid dying in an intensive care unit (AOR = 1.36, 95% CI:1.05–1.76). Scores indicating greater acculturation were also associated with increased odds of patient participation in clinical trials (AOR = 2.20, 95% CI:1.28–3.78), compared with lower USAS scores, and greater odds of patients receiving chemotherapy (AOR = 1.59, 95% CI:1.20–2.12). Conclusion: The USAS is a reliable and valid measure of ‘‘Americanization’’ associated with advanced cancer patients’ end-of-life preferences and care. USAS scores indicating greater caregiver acculturation were associated with increased odds of patient participation in cancer treatment (chemotherapy, clinical trials) compared with lower scores. Future studies should examine the effects of acculturation on end-of-life care to identify patient and provider factors that explain these effects and targets for future interventions to improve care (e.g., by designing more culturally-competent health education materials).
Comments

This research was supported in part by the following grants to Dr. Prigerson: MH63892 from the National Institute of Mental Health and CA 106370 and CA 156732 from the National Cancer Institute; by Career Development Awards sponsored by the Conquer Cancer Foundation of the American Society of Clinical Oncology, the National Palliative Care Research Center, and the American Cancer Society to Dr. Wright; and by the Center for Psychosocial Epidemiology and Outcomes Research, Dana-Farber Cancer Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Community Engaged/Serving
No, this is not community-engaged.
Publisher
PLOS ONE
Rights
© 2013 Wright et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Creative Commons License
Creative Commons Attribution 4.0
Citation Information
Wright AA, Stieglitz H, Kupersztoch YM, Paulk ME, Kim Y, et al. (2013) United States Acculturation and Cancer Patients’ End-of-Life Care. PL S ONE 8(3): e58663. doi:10.1371/journal.pone.0058663