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CRIP1a switches cannabinoid receptor agonist/antagonist-mediated protection from glutamate excitotoxicity
Neuroscience letters
  • Brandon Stauffer
  • Kathleen Wallis
  • Steven Wilson
  • Michaela Egertovac
  • Maurice R. Elphick
  • Deborah L. Lewis
  • Lori Redmond Hardy, Philadelphia College of Osteopathic Medicine
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A shared pathology among many neurological and neurodegenerative disorders is neuronal loss. Cannabinoids have been shown to be neuroprotective in multiple systems. However, both agonists and antagonists of the CB 1 cannabinoid receptor are neuroprotective, but the mechanisms responsible for these actions remain unclear. Recently a CB 1 receptor interacting protein, CRIP1a, was identified and found to alter CB 1 activity. Here we show that in an assay of glutamate neurotoxicity in primary neuronal cortical cultures CRIP1a disrupts agonist-induced neuroprotection and confers antagonist-induced neuroprotection. © 2011 Elsevier Ireland Ltd.

This article was published in Neuroscience letters, Volume 503, Issue 3, Pages 224-228.

The published version is available at

Copyright © 2011 Elsevier.

Citation Information
Brandon Stauffer, Kathleen Wallis, Steven Wilson, Michaela Egertovac, et al.. "CRIP1a switches cannabinoid receptor agonist/antagonist-mediated protection from glutamate excitotoxicity" Neuroscience letters Vol. 503 Iss. 3 (2011) p. 224 - 228
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