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Nuclear Notch1 signaling and the regulation of dendritic development
Nature neuroscience
  • Lori Redmond Hardy, Philadelphia College of Osteopathic Medicine
  • Sang-rog Oh
  • Carol Hicks
  • Gerry Weinmaster
  • Anirvan Ghosh
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To understand the function of Notch in the mammalian brain, we examined Notch1 signaling and its cellular consequences in developing cortical neurons. We found that the cytoplasmic domain of endogenous Notch1 translocated to the nucleus during neuronal differentiation. Notch1 cytoplasmic-domain constructs transfected into cortical neurons were present in multiple phosphorylated forms, localized to the nucleus and could induce CBF1-mediated transactivation. Molecular perturbation experiments suggested that Notch1 signaling in cortical neurons promoted dendritic branching and inhibited dendritic growth. These observations show that Notch1 signaling to the nucleus exerts an important regulatory influence on the specification of dendritic morphology in neurons.

This article was published in Nature neuroscience, Volume 3, Issue 1, Pages 30-40.

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Copyright © 2000 Nature Publishing Group.

Citation Information
Lori Redmond Hardy, Sang-rog Oh, Carol Hicks, Gerry Weinmaster, et al.. "Nuclear Notch1 signaling and the regulation of dendritic development" Nature neuroscience Vol. 3 Iss. 1 (2000) p. 30 - 40
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