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Article
Instabilities in multiserotype disease models with antibody-dependent enhancement
Journal of Theoretical Biology (2006)
  • Lora Billings, Montclair State University
  • Ira Schwartz, US Naval Research Labratory
  • Leah B Shaw, US Naval Research Labratory
  • Marie McCrary, Montclair State University
  • Donald S Burke, Johns Hopkins Bloomberg School of Public Health
  • Derek A.T. Cummings, Johns Hopkins Bloomberg School of Public Health
Abstract
This paper investigates the complex dynamics induced by antibody-dependent enhancement (ADE) in multiserotype disease models. ADE is the increase in viral growth rate in the presence of immunity due to a previous infection of a different serotype. The increased viral growth rate is thought to increase the infectivity of the secondary infectious class. In our models, ADE induces the onset of oscillations without external forcing. The oscillations in the infectious classes represent outbreaks of the disease. In this paper, we derive approximations of the ADE parameter needed to induce oscillations and analyze the associated bifurcations that separate the types of oscillations. We then investigate the stability of these dynamics by adding stochastic perturbations to the model. We also present a preliminary analysis of the effect of a single serotype vaccination in the model.
Keywords
  • Epidemics,
  • Multiserotype,
  • Antibody-dependent enhancement,
  • Dengue,
  • Vaccine
Disciplines
Publication Date
Winter December 28, 2006
DOI
10.1016/j.jtbi.2006.12.023
Citation Information
Lora Billings, Ira Schwartz, Leah B Shaw, Marie McCrary, et al.. "Instabilities in multiserotype disease models with antibody-dependent enhancement" Journal of Theoretical Biology (2006) ISSN: 1095-8541
Available at: http://works.bepress.com/lora-billings/21/