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Thymus Transcriptome Response to Avian Pathogenic E. coli (APEC) Infection
Animal Industry Report
  • Hongyan Sun, Iowa State University
  • Peng Liu, Iowa State University
  • Lisa K. Nolan, Iowa State University
  • Susan J. Lamont, Iowa State University
Extension Number
ASL R2992
Publication Date
2015
Topic
Poultry
Summary and Implications

Colibacillosis, caused by avian pathogenic Escherichia coli (APEC), is responsible for multi-million dollar losses in the poultry industry every year in the United States. Therefore, it is important to understand the functional genomics of avian response to APEC, to find effective control strategies. The transcriptome characterizes genetic elements that are expressed. The thymus transcriptomes of 24 birds with known challenge status, necropsy day, and pathology level were sequenced using RNA-Seq. Many innate immune response pathways were significantly changed. Differentially expressed (DE) genes analysis showed APEC infection affected immune homeostasis through impairing the engagement of regulatory signal transduction pathways for T cell development. This study gives insight into T cell development and immune response under APEC infection. The DE gene analysis revealed gene networks that affect T cell development as well as immune homeostasis following APEC infection. These results add knowledge of host immune response to APEC infection.

Copyright Holder
Iowa State University
Language
en
Citation Information
Hongyan Sun, Peng Liu, Lisa K. Nolan and Susan J. Lamont. "Thymus Transcriptome Response to Avian Pathogenic E. coli (APEC) Infection" (2015)
Available at: http://works.bepress.com/lisa_nolan/89/