Most patients with intracranial germinomas will be cured and become long-term survivors. Physicians caring for these patients should recognize that these patients may be at risk for disease-related and/or treatment-related late sequelae. We report the case of a 27-year-old man who developed testicular seminoma 16 years after treatment for intracranial germinoma. Like their testicular cancer counterparts, long-term survivors of intracranial germinomas may have a susceptibility to develop a subsequent germ cell tumor. These patients require lifelong medical follow-up and should be encouraged to perform testicular self-examination at the appropriate age.
Maity, A., Shu, H. G., Judkins, A. R., Fisher, M. J., Dwyer-Joyce, L. A., & Vaughn, D. J. (2004). Testicular seminoma 16 years after treatment for CNS germinoma. Journal Of Neuro-Oncology, 70(1), 83-85.