Skip to main content
Next-Generation Heteronuclear Decoupling for High-Field Biomolecular NMR Spectroscopy
Angewandte Chemie (2014)
  • Franz Schilling, Technische Universität München
  • Lisa R. Warner, Helmholtz Zentrum München
  • Naum I. Gershenzon, Wright State University
  • Thomas E. Skinner, Wright State University
  • MIchael Sattler, Helmholtz Zentrum München
  • Steffen J. Glaser, Technische Universität München
Ultra-high-field NMR spectroscopy requires an increased bandwidth for heteronuclear decoupling, especially in biomolecular NMR applications. Composite pulse decoupling cannot provide sufficient bandwidth at practical power levels, and adiabatic pulse decoupling with sufficient bandwidth is compromised by sideband artifacts. A novel low-power, broadband heteronuclear decoupling pulse is presented that generates minimal, ultra-low sidebands. The pulse was derived using optimal control theory and represents a new generation of decoupling pulses free from the constraints of periodic and cyclic sequences. In comparison to currently available state-of-the-art methods this novel pulse provides greatly improved decoupling performance that satisfies the demands of high-field biomolecular NMR spectroscopy.
  • NMR spectroscopy,
  • nucleic acids,
  • proteins,
  • decoupling sidebands,
  • ultra-broadband decoupling
Publication Date
April 22, 2014
Citation Information
Franz Schilling, Lisa R. Warner, Naum I. Gershenzon, Thomas E. Skinner, et al.. "Next-Generation Heteronuclear Decoupling for High-Field Biomolecular NMR Spectroscopy" Angewandte Chemie Vol. 53 Iss. 17 (2014) p. 4475 - 4479
Available at: