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Article
Feline dry eye syndrome of presumed neurogenic origin: a case report
Journal of Feline Medicine and Surgery Open Reports
  • Lionel Sebbag, Iowa State University
  • Patricia A. Pesavento, University of California, Davis
  • Sebastian E. Carrasco, University of California, Davis
  • Christopher M. Reilly, University of California, Davis
  • David J. Maggs, University of California, Davis
Document Type
Article
Publication Version
Published Version
Publication Date
1-1-2018
DOI
10.1177%2F2055116917746786
Abstract

Case summary A 14-year-old female spayed Abyssinian cat, which about 1 year previously underwent thoracic limb amputation, radiotherapy and chemotherapy for an incompletely excised vaccine-related fibrosarcoma, was presented for evaluation of corneal opacity in the left eye (OS). The ocular surface of both eyes (OU) had a lackluster appearance and there was a stromal corneal ulcer OS. Results of corneal aesthesiometry, Schirmer tear test-1 (STT-1) and tear film breakup time revealed corneal hypoesthesia, and quantitative and qualitative tear film deficiency OU. Noxious olfactory stimulation caused increased lacrimation relative to standard STT-1 values suggesting an intact nasolacrimal reflex. Various lacrimostimulants were administered in succession; namely, 1% pilocarpine administered topically (15 days) or orally (19 days), and topically applied 0.03% tacrolimus (47 days). Pilocarpine, especially when given orally, was associated with notable increases in STT-1 values, but corneal ulceration remained/recurred regardless of administration route, and oral pilocarpine resulted in gastrointestinal upset. Tacrolimus was not effective. After 93 days, the cat became weak and lame and a low thyroxine concentration was detected in serum. The cat was euthanized and a necropsy performed. Both lacrimal glands were histologically normal, but chronic neutrophilic keratitis and reduced conjunctival goblet cell density were noted OU.

Relevance and novel information The final diagnosis was dry eye syndrome (DES) of presumed neurogenic origin, associated with corneal hypoesthesia. This report reinforces the importance of conducting tearfilm testing in cats with ocular surface disease, as clinical signs of DES were different from those described in dogs.

Comments

This article is published as Sebbag, Lionel, Patricia A. Pesavento, Sebastian E. Carrasco, Christopher M. Reilly, and David J. Maggs. "Feline dry eye syndrome of presumed neurogenic origin: a case report." Journal of Feline Medicine and Surgery Open Reports 4, no. 1 (2017): 2055116917746786. DOI: 10.1177%2F2055116917746786. Posted with permission.

Creative Commons License
Creative Commons Attribution-Noncommercial 4.0
Copyright Owner
The Author(s)
Language
en
File Format
application/pdf
Citation Information
Lionel Sebbag, Patricia A. Pesavento, Sebastian E. Carrasco, Christopher M. Reilly, et al.. "Feline dry eye syndrome of presumed neurogenic origin: a case report" Journal of Feline Medicine and Surgery Open Reports Vol. 4 Iss. 1 (2018) p. 2055116917746786
Available at: http://works.bepress.com/lionel-sebbag/5/