Patellofemoral syndrome (PFS), also known as patellofemoral pain syndrome (PFPS) and runner's knee, is one of the most common causes of anterior knee pain encountered by clinicians. Patients typically complain of generalized anterior knee pain that is aggravated by loading a flexed knee such as running, climbing stairs, and squatting. PFS is considered a diagnosis of exclusion once intraarticular or peripatellar pathologies are ruled out. The majority of patients with PFS experience a resolution of symptoms with conservative treatments, though in some rare cases may be resistant to therapies and be persistent for years.