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Article
Steroidogenic Response of Adrenal Tissues after Administration of ACTH to Dogs with Hypercortisolemia
Journal of the American Veterinary Medical Association (2001)
  • Linda Frank, University of Tennessee - Knoxville
  • Lynn P. Schmeitzel, University of Tennessee - Knoxville
  • Jack W. Oliver, University of Tennessee - Knoxville
Abstract
Objective—To evaluate adrenal sex hormone concentrations in neutered dogs with hypercortisolemia. Design—Case series. Animals—11 neutered dogs with hypercortisolemia. Procedure—Serum samples obtained before and 1 hour after administration of ACTH were evaluated for concentrations of cortisol, progesterone, testosterone, dehydroepiandrosterone sulfate or androstenedione or both, and 17-hydroxyprogesterone. Results—For all dogs, concentrations of 1 or more adrenal sex hormones were substantially greater than reference range values before or after administration of ACTH. Testosterone concentration was not greater than reference range values in any of the dogs. Conclusions and Clinical Relevance—Results emphasize the importance of ruling out hypercortisolemia before measuring adrenal sex hormone concentrations as a means of diagnosing adrenal hyperplasia syndrome (alopecia X) in dogs.
Publication Date
January 15, 2001
Citation Information
Linda Frank, Lynn P. Schmeitzel and Jack W. Oliver. "Steroidogenic Response of Adrenal Tissues after Administration of ACTH to Dogs with Hypercortisolemia" Journal of the American Veterinary Medical Association Vol. 218 Iss. 2 (2001)
Available at: http://works.bepress.com/linda_frank/36/