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Article
Screening of some Australian Flacourtiaceae species for in vitro antioxidant, cytotoxic and antimicrobial activity
Phytomedicine
  • M Ashik Mosaddik, Southern Cross University
  • Linda K Banbury, Southern Cross University
  • Paul I Forster, Brisbane Botanical Gardens
  • Ron Booth, Brisbane Botanical Gardens
  • Julie L Markham, Southern Cross University
  • David N Leach, Southern Cross University
  • Peter G Waterman, Southern Cross University
Document Type
Article
Publication Date
1-1-2004
Peer Reviewed
Peer-Reviewed
Abstract
A total of 27 methanol extracts obtained from different plant parts of 10 species of rain forest trees belonging to four genera of the Flacourtiaceae and originating from Australia were investigated. In vitro cytotoxicity was measured by an ATP Lite-M assay method against the mouse P388 lymphocytic leukemia cell line. The total antioxidant activity has been assessed based on scavenging activity of stable ABTS free radicals. The minimum inhibition concentration (MIC) was determined by the dilution method performed in 96 well plates against four different microbes. The leaf extract of Casearia sp. (RB 3051), mature stem extract of Casearia grayi and stem extract of Scolopia braunii were found to have most antioxidant activity (IC50=2.9 μg/ml), cytotoxic activity (LC50=0.89 μg/ml) and antimicrobial activity against all four different microbes, respectively. The results obtained suggested that among the four genera studied Casearia is the most promising in respect of finding significant antioxidant, cytotoxic and also antimicrobial activity.
Disciplines
Citation Information

Mosaddik, MA, Banbury, LK, Forster, PI, Booth, R, Markham, J, Leach, DN & Waterman, PG 2004, 'Screening of some Australian Flacourtiaceae species for in vitro antioxidant, cytotoxic and antimicrobial activity', Phytomedicine, vol. 11, no. 5, pp. 461-466.

Published version available from:

http://dx.doi.org/10.1016/j.phymed.2003.12.001

Linda Banbury has also published under the name of Linda McClure