Rhodium-Catalyzed, Enantioselective Hydroacylation of ortho-AllylbenzaldehydesOrganic Letters
Publication VersionPublished Version
AbstractThe development of a rhodium catalyst for endo- and enantioselective hydroacylation ofortho-allylbenzaldehydes is reported. A catalyst generated in situ from [Rh(COD)Cl]2, (R)-DTBM-SEGPHOS, and NaBARF promotes the desired hydroacylation reactions and minimizes the formation of byproducts from competitive alkene isomerization and ene/dehydration pathways. These rhodium-catalyzed processes generate the 3,4-dihydronaphthalen-1(2H)-one products in moderate-to-high yields (49–91%) with excellent enantioselectivities (96–99% ee).
Copyright OwnerAmerican Chemical Society
Citation InformationKirsten F. Johnson, Adam C. Schmidt and Levi M. Stanley. "Rhodium-Catalyzed, Enantioselective Hydroacylation of ortho-Allylbenzaldehydes" Organic Letters Vol. 17 Iss. 19 (2015) p. 4654 - 4657
Available at: http://works.bepress.com/levi_stanley/1/