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HDL-cholesterol-raising Effect of Orange Juice in Subjects with Hypercholesterolemia
American Journal of Clinical Nutrition
  • Elzbieta M. Kurowska, University of Western Ontario
  • J. David Spence, Robarts Research Institute
  • John Jordan, University of Western Ontario
  • Stephen Wetmore, University of Western Ontario
  • David J. Freeman, University of Western Ontario
  • Leonard A. Piché, University of Western Ontario - Brescia College
  • Paula Serratore, YMCA, London, Canada
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Background: Orange juice-a rich source of vitamin C, folate, and flavonoids such as hesperidin-induces hypocholesterolemic responses in animals.

Objective: We determined whether orange juice beneficially altered blood lipids in subjects with moderate hypercholesterolemia.

Design: The sample consisted of 16 healthy men and 9 healthy women with elevated plasma total and LDL-cholesterol and normal plasma triacylglycerol concentrations. Participants incorporated 1, 2, or 3 cups (250 mL each) of orange juice sequentially into their diets, each dose over a period of 4 wk. This was followed by a 5-wk washout period. Plasma lipid, folate, homocyst(e)ine, and vitamin C (a compliance marker) concentrations were measured at baseline, after each treatment, and after the washout period.

Results: Consumption of 750 mL but not of 250 or 500 mL orange juice daily increased HDL-cholesterol concentrations by 21% (P: < 0.001), triacylglycerol concentrations by 30% (from 1.56 +/- 0.72 to 2.03 +/- 0.91 mmol/L; P: < 0.02), and folate concentrations by 18% (P: < 0.01); decreased the LDL-HDL cholesterol ratio by 16% (P: < 0.005); and did not affect homocyst(e)ine concentrations. Plasma vitamin C concentrations increased significantly during each dietary period (2.1, 3.1, and 3.8 times, respectively).

Conclusions: Orange juice (750 mL/d) improved blood lipid profiles in hypercholesterolemic subjects, confirming recommendations to consume >/=5-10 servings of fruit and vegetables daily.

Citation Information
Elzbieta M. Kurowska, J. David Spence, John Jordan, Stephen Wetmore, et al.. "HDL-cholesterol-raising Effect of Orange Juice in Subjects with Hypercholesterolemia" American Journal of Clinical Nutrition Vol. 72 Iss. 5 (2000) p. 1095 - 1100
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