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Article
Assessing disulfiram compliance: validational study of an abbreviated breath test procedure
Systems and Psychosocial Advances Research Center Publications and Presentations
  • Robert G. Rychtarik, University of Mississippi Medical Center
  • Patrick O. Smith, University of Mississippi Medical Center
  • Stanton L. Jones, University of Mississippi Medical Center
  • Leonard A. Doerfler, University of Massachusetts Medical School
  • Ray Hale, University of Mississippi Medical Center
  • Donald M. Prue, University of Mississippi Medical Center
UMMS Affiliation
Department of Psychiatry
Date
1-1-1983
Document Type
Article
Medical Subject Headings
Adult; Alcoholism; Breath Tests; Carbon Disulfide; Disulfiram; Humans; Male; *Patient Compliance; Spectrophotometry
Abstract
An abbreviated breath test for detecting the disulfiram metabolite carbon disulfide (CS2) was evaluated in an analogue investigation of the sensitivity of the test in identifying disulfiram and non-disulfiram intake in a group of 14 alcoholic inpatients. Disulfiram (250 mg) was administered within an ABAB repeated measures design over a 12-day period with corresponding breath tests administered during morning and afternoon time periods. Dependent measures included spectrophotometric analysis of reacted test samples and visual ratings of sample color. Results indicated that the test was highly sensitive in discriminating disulfiram administration for the group as a whole, as well as for individual subjects. Moreover, visual ratings were more accurate than spectrophotometric cut-off scores in identifying disulfiram administration. The test shows considerable promise as a rapid means of assessing disulfiram compliance.
Comments

Citation: Addict Behav. 1983;8(4):361-8. DOI 10.1016/0306-4603(83)90036-9

At the time of publication, Leonard Doerfler was not yet affiliated with the University of Massachusetts Medical School.

Related Resources
Link to Article in PubMed
Citation Information
Robert G. Rychtarik, Patrick O. Smith, Stanton L. Jones, Leonard A. Doerfler, et al.. "Assessing disulfiram compliance: validational study of an abbreviated breath test procedure" Vol. 8 Iss. 4 (1983) ISSN: 0306-4603 (Linking)
Available at: http://works.bepress.com/leonard_doerfler/7/