Nondestructive testing (NDT) is a mature industry, with global equipment sales fast moving towards $2B. per year. The use of conventional NDT will grow in developing countries and in developed countries the challenges will include those associated with maintaining aging infrastructure. For some systems the future will move to structural health monitoring (SHM) and for others into integration of online measurements in manufacturing. Nondestructive Evaluation (NDE) is a multi-disciplinary area of endeavor that has its origins in materials science and NDT. It seeks to provide an adequate science base for NDT to become a quantitative science. It was seen to be necessary to better detect, size and type defects, improve the reliability of inspection, and probability of detection (POD). There is particular interest in estimating the potential defects could have on performance or potential for loss of structural integrity, under various loading or stressor conditions, and ultimately implement risk-based reliability assessments. NDE must be seen more as a part of the wide field of engineering, as an interdisciplinary endeavor, that brings together the expertise of materials science and metrology, together with the underlying physics for inspection methods, as well as statistics, computers, robotics and software. The adoption of advanced manufacturing, will require new metrology tools and methods to provide data for assessing new materials including powder metals, as used in additive manufacturing, and various composites. The lessons from the past proceedings of this conference series include that the problems faced today are harder than was expected during the first decade of quantitative NDE research. Even with new types of transducers and much improved A/D and powerful computers new approaches and more basic measurement physics being understood, new insights are needed to provide the data needed to solve many real-world NDE problems, to understand and measure early degradation and to give the required data for remaining safe life or prognostic prediction.