This article explores the flaked stone assemblage and associated materials from Mission Santa Cantalina, Baja California, with a particular focus on possible continuities and changes over time in the lithic technologies employed by the indigenous inhabitants of the region. Issues such as raw material procurement and lithic reduction strategies will be examined to understand how mission neophytes used stone tools and the ways in which lithic artifacts may shed further light on the social context of native life at the mission. Overall, the lithic assemblage points toward the continuation of some important aspects of stone tool technologies but also a general de-emphasis of the role of flaked stone tools during the colonial period.