Article
Catalyst-Controlled Formal [4 + 3] Cycloaddition Applied to the Total Synthesis of (+)-Barekoxide and (−)-Barekol
Journal of the American Chemical Society
(2010)
Abstract
The development of new approaches for the treatment of antimicrobial-resistant infections is an urgent public health priority. The Pseudomonas aeruginosa pathogen, in particular, is a leading source of infection in hospital settings, with few available treatment options. In the context of an effort to develop antivirulence strategies to combat bacterial infection, we identified a series of highly effective small molecules that inhibit the production of pyocyanin, a redox-active virulence factor produced by P. aeruginosa. Interestingly, these new antagonists appear to suppress P. aeruginosa virulence factor production through a pathway that is independent of LasR and RhlR.
Disciplines
Publication Date
August 12, 2010
Publisher Statement
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Citation Information
Yajing Lian, Laura C. Miller, Stephen Born, Richmond Sarpong, et al.. "Catalyst-Controlled Formal [4 + 3] Cycloaddition Applied to the Total Synthesis of (+)-Barekoxide and (−)-Barekol" Journal of the American Chemical Society Vol. 132 Iss. 35 (2010) Available at: http://works.bepress.com/laura_millerconrad/3/