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Article
Early detection of stage A prostate carcinoma: Combined use of prostate- specific antigen and transrectal ultrasonography
Journal of the American Osteopathic Association
  • R. L. Fiorelli
  • R. L. Klaus
  • S. J. Manfrey
  • Laurence Belkoff, Philadelphia College of Osteopathic Medicine
  • Larry Finkelstein, Philadelphia College of Osteopathic Medicine
Document Type
Article
Publication Date
1-1-1991
Disciplines
Abstract
We prospectively studied 103 men who had normal results on digital prostate examinations but had bladder outlet obstruction secondary to prostatic hypertrophy and needed transurethral prostatectomy. All men underwent a preoperative transrectal ultrasonographic examination of the prostate and prostate-specific antigen (PSA) level determination. A total of 30 cancers were ultimately detected, 22 (73%) of which were detected preoperatively by either an abnormal ultrasonogram or elevated PSA levels (or both). Eight of these men were spared transurethral prostatectomy and had definitive treatment based on transrectal biopsy and appropriate staging evaluation. For PSA and ultrasonography combined, the sensitivities and negative predictive values for cancer (92% and 94%, respectively) were superior to the specificities and positive predictive values (71% and 64%, respectively). The combined use of both studies is recommended to rule out cancer in candidates for prostatectomy but not to routinely screen the general male population older than 40 years.
Comments

This article was published in Journal of the American Osteopathic Association, Volume 91, Issue 9, Pages 863-870.

The published version is not available online.
Citation Information
R. L. Fiorelli, R. L. Klaus, S. J. Manfrey, Laurence Belkoff, et al.. "Early detection of stage A prostate carcinoma: Combined use of prostate- specific antigen and transrectal ultrasonography" Journal of the American Osteopathic Association Vol. 91 Iss. 9 (1991) p. 863 - 870
Available at: http://works.bepress.com/larry_finkelstein/7/