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Selected Works of Lark Perez
Article
Highly potent, chemically stable quorum sensing agonists for vibrio Cholerae
Chemical Science (2014)
  • Dr. Lark Perez, Rowan University
  • Theodora K. Karagounis
  • Amanda Hurley
  • Bonnie L. Bassler, Princeton University
  • Martin F. Semmelhack, Princeton University
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Abstract
In the Vibrio cholerae pathogen, initiation of bacterial quorum sensing pathways serves to suppress virulence. We describe herein a potent and chemically stable small molecule agonist of V. cholerae quorum sensing, which was identified through rational drug design based on the native quorum sensing signal. This novel agonist may serve as a useful lead compound for the control of virulence in V. cholerae.
Disciplines
Publication Date
January, 2014
DOI
10.1039/C3SC52572D
Citation Information
Lark Perez, Theodora K. Karagounis, Amanda Hurley, Bonnie L. Bassler, et al.. "Highly potent, chemically stable quorum sensing agonists for vibrio Cholerae" Chemical Science Vol. 5 (2014) p. 151 - 155 ISSN: 2041-6520
Available at: http://works.bepress.com/lark-perez/4/