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Selected Works of Lark Perez
Article
Modulating Vibrio cholerae Quorum-Sensing-Controlled Communication Using Autoinducer-Loaded Nanoparticles
Nano letters (2015)
  • Hoang D. Lu
  • Alina C. Spiegel
  • Amanda Hurley
  • Dr. Lark Perez, Rowan University
  • Katharina Maisel
  • Laura M. Ensign
  • Justin Hanes
  • Bonnie L. Bassler, Princeton University
  • Martin F. Semmelhack, Princeton University
  • Robert K. Prud'homme
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Abstract
The rise of bacterial antibiotic resistance has created a demand for alternatives to traditional antibiotics. Attractive possibilities include pro- and anti-quorum sensing therapies that function by modulating bacterial chemical communication circuits. We report the use of Flash NanoPrecipitation to deliver the Vibrio cholerae quorum-sensing signal CAI-1 ((S)-3-hydroxytridecan-4-one) in a water dispersible form as nanoparticles. The particles activate V. cholerae quorum-sensing responses 5 orders of magnitude higher than does the identically administered free CAI-1 and are diffusive across in vivo delivery barriers such as intestinal mucus. This work highlights the promise of combining quorum-sensing strategies with drug delivery approaches for the development of next-generation medicines.
Keywords
  • autoinducer,
  • CAI-1,
  • drug delivery,
  • Nanoparticle,
  • quorum sensing,
  • Vibrio cholerae
Disciplines
Publication Date
April, 2015
DOI
10.1021/acs.nanolett.5b00151
Citation Information
Hoang D. Lu, Alina C. Spiegel, Amanda Hurley, Lark Perez, et al.. "Modulating Vibrio cholerae Quorum-Sensing-Controlled Communication Using Autoinducer-Loaded Nanoparticles" Nano letters Vol. 15 Iss. 4 (2015) p. 2235 - 2241 ISSN: 1530-6984
Available at: http://works.bepress.com/lark-perez/3/