Article
Potent Irreversible Inhibitors of LasR Quorum Sensing in Pseudomonas aeruginosa
ACS Medicinal Chemistry Letters
(2015)
Abstract
Antagonism of quorum sensing represents a promising new antivirulence approach for the treatment of bacterial infection. The development of a novel series of non-natural irreversible antagonists of P. aeruginosa LasR is described. The lead compounds identified (25 and 28) display potent LasR antagonist activity and inhibit expression of the P. aeruginosa virulence factors pyocyanin and biofilm formation in PAO1 and PA14.
Keywords
- antivirulence,
- biofilm inhibition,
- Pseudomonas aeruginosa,
- quorum sensing,
- structure−activity relationship
Disciplines
Publication Date
February, 2015
DOI
10.1021/ml500459f
Citation Information
Kevin T. O'Brien, Joseph G. Noto, Luke Nichols-O'Neill and Lark Perez. "Potent Irreversible Inhibitors of LasR Quorum Sensing in Pseudomonas aeruginosa" ACS Medicinal Chemistry Letters Vol. 6 Iss. 2 (2015) p. 162 - 167 ISSN: 1948-5875 Available at: http://works.bepress.com/lark-perez/2/