Dynamic modeling and field testing of full-scale window systems using a shock tube are presented in this paper. The modeling includes numerical simulations using LSDYNA. The dynamic response in terms of the center deflection as well as the dynamic reactions around the window frame is measured and compared to the modeling results. In addition to the positive phase of the blast loading, the response of the window system to negative phase is also investigated. The modeled dynamic deflections and reactions correlated well within the first few peaks of the measured response of the window systems. The results of this study can be used to improve the existing methods for predicting the dynamic response of windows under blast and to provide affordable design recommendations.