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Article
Regulation of Hepatocyte Fate by Interferon-γ
Cytokine & Growth Factor Reviews (2011)
  • Christopher J. Horras, Boise State University
  • Cheri L. Lamb, Boise State University
  • Kristen A. Mitchell, Boise State University
Abstract
Interferon (IFN)-γ is a cytokine known for its immunomodulatory and anti-proliferative action. In the liver, IFN-γ can induce hepatocyte apoptosis or inhibit hepatocyte cell cycle progression. This article reviews recent mechanistic reports that describe how IFN-γ may direct the fate of hepatocytes either towards apoptosis or a cell cycle arrest. This review also describes a probable role for IFN-γ in modulating hepatocyte fate during liver regeneration, transplantation, hepatitis, fibrosis and hepatocellular carcinoma, and highlights promising areas of research that may lead to the development of IFN-γ as a therapy to enhance recovery from liver disease.
Keywords
  • IFN-γ,
  • hepatocyte,
  • liver,
  • proliferation,
  • apoptosis
Disciplines
Publication Date
February 1, 2011
Publisher Statement
Cytokine & Growth Factor Reviews, Volume 22, Issue 1, 35-43. DOI: 10.1016/j.cytogfr.2011.01.001
Citation Information
Christopher J. Horras, Cheri L. Lamb and Kristen A. Mitchell. "Regulation of Hepatocyte Fate by Interferon-γ" Cytokine & Growth Factor Reviews Vol. 22 Iss. 1 (2011)
Available at: http://works.bepress.com/kristen_mitchell/32/