Abstract Purpose Tanzanian children with surgically correctable disabilities face challenges in accessing healthcare and cultural and societal stigma and prejudice. This paper provides insight into the staf perceptions from one rehabilitation center in Tanzania, The Plaster House, pertaining to disability, treatment, and change broadly for children with disabilities who receive treatments. Methods This was a qualitative content analysis. As part of a program evaluation, semi-structured interviews were conducted with 32 staf members of The Plaster House, gaining perceptions about change for children with disabilities receiving treatments. The Community-Based Rehabilitation (CBR) Matrix was utilized to organize the data into categories and form results. Results Themes were identifed and organized within the following categories in the CBR Matrix: health, rehabilitation, education, social roles, and empowerment. Each was associated with the child or family caregiver experience at The Plaster House. Conclusion Findings provided rare insight from Tanzanian staf on the valuable social, emotional, and physical impacts of specialized treatment for children with disabilities and their parents. Transformational changes are possible for children with disabilities and their families despite poverty and limited access to services.