We utilize duoethnography to help readers better understand the constitutive nature of disability in the contexts of chronic illness and mental health. By doing so, we articulate the concept of socio-emotional disablism, which expands structural and psycho-emotional theories of disablism to account for the ways socio-material interactions trigger emotion-work—the communicative labor and fatigue that accompanies negotiating our own emotions as well as the emotions of others in disabling contexts—thus limiting relational and ideological engagement with disability. We conclude by discussing what the concept of socio-emotional disablism teaches us about how to build more inclusive social futures through deeper interpersonal engagement and more sustainable public health practices.