About Kim Lewis
The focus of my research is on antimicrobial drug tolerance and drug discovery. Microorganisms produce persister cells, which are dormant variants that are highly tolerant to killing by all known antibiotics. Persisters are largely responsible for relapsing chronic infections caused by biofilms. Using transcriptome analysis, cell sorting and whole genome sequencing we are identifying genes responsible for persister formation. Both drug tolerance and conventional drug resistance require development of new antibiotics, and our discovery efforts include screening compounds from previously "uncultured" species of microorganisms, and high-throughput screening for compounds with novel mode of action.
Department of Biology
405 Mugar Life Sciences
360 Huntington Avenue
Boston, MA 02115
Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation ...
Antimocrobial Agents and Chemotherapy (2010)
Hybrid antimicrobials containing an antibacterial linked to a multidrug resistance (MDR) pump inhibitor make up a promising new class of ...
SOS response induces persistence to fluoroquinolones in Escherichia coli
Biology Faculty Publications (2009)
Bacteria can survive antibiotic treatment without acquiring heritable antibiotic resistance. We investigated persistence to the fluoroquinolone ciprofloxacin in Escherichia coli. ...