Teenagers face many factors that impact their brains. Factors ranging from technology to trauma physiologically alter the teenage brain. For educators to support their students, they require a foundational understanding of how technology and trauma impact the teen brain. Teenage students report record high levels of stress in their young lives. Students report stress levels equal to those of their parents and other adults. Teachers are trying to work with classes in which a majority of students report they have had to deal with trauma and other kinds of stress in school and online. To mitigate these issues, teachers must assist students by fostering self-regulation skills. Further, teachers must help students by buffering the effects of trauma and stress by nurturing strong and caring relationships with students. When teachers understand the interrelationship between regulation and strong relationships, they will be able to provide students with vital skills needed for their success. As foundational skills, regulation and relationships are the new rites of passage for today’s teenagers. This paper examines current research literature associated with the brain, self-regulation, and relationships.