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Article
Cellular Automata Simulation of Osteoblast Growth on Microfibrous-Carbon-Based Scaffolds
Tissue Engineering Part A
  • Jarema S. Czarnecki, University of Dayton
  • Simon Jolivet, University of Dayton
  • Mary Blackmore, Center for Tissue, Innovation & Research
  • Khalid Lafdi, University of Dayton
  • Panagiotis A. Tsonis, University of Dayton
Document Type
Article
Publication Date
12-1-2014
Abstract

The objective of this study was to investigate the use of three fibrous carbon materials (T300, P25, and P120) for bone repair and develop and validate theoretical and computational methods in which bone tissue regeneration and repair could be accurately predicted. T300 was prepared from polyacrylonitrile precursor while P25 and P120 fibers were prepared from pitch, both common fiber precursors. Results showed that osteoblast growth on carbon scaffolds was enhanced with increased crystallinity, surface roughness, and material orientation. For unidirectional scaffolds at 120 h, there was 33% difference in cell growth between T300 and P25 fibers and 64% difference between P25 and P120 fibers. Moreover, for multidirectional fibers at 120 h, there was 35% difference in cell growth between T300 and P25 fibers and 43% difference between P25 and P120 fibers. Results showed that material alignment was integral to promoting cell growth with multidirectional scaffolds having the capacity for greater growth over unidirectional scaffolds. At 120 h there was 24% increase in cell growth between unidirectional alignment and multidirectional alignment on high-crystalline carbon fibers. Ultimately, data indicated that carbon scaffolds exhibited excellent bioactivity and may be tuned to stimulate unique reactions. Additionally, numerical and computational simulations provided evidence that corroborated experimental data with simulations. Results illustrated the capability of cellular automata models for assessing osteoblast cell response to biomaterials.

Inclusive pages
3176-3188
ISBN/ISSN
1937-3368
Publisher
Mary Ann Liebert Publishers
Peer Reviewed
Yes
Citation Information
Jarema S. Czarnecki, Simon Jolivet, Mary Blackmore, Khalid Lafdi, et al.. "Cellular Automata Simulation of Osteoblast Growth on Microfibrous-Carbon-Based Scaffolds" Tissue Engineering Part A Vol. 20 Iss. 23-24 (2014)
Available at: http://works.bepress.com/khalid_lafdi/107/